Hi,
First a note:
The transcoder and tools are in an early stage. Suitable for people which want to experiment.
Everything is done for the UPmini (other printers might need some adjustments / enhancements in the source code).

In the first version I set the nozzle height to a fixed value (in the transcoder, no option yet) , which turned out to work 100% perfect on 4 different UP mini I tested. Also the printer will automatically pre heat the bed for 3 minutes (fixed) before starting the actual print.
So don't expect to much right now, but please experiment with it in case you want to support the project.
My initial findings for Simplify3D settings:
Type: Cartesian robot
Firmware: RepRap
BaudRate: <doesn't matter we don't Simplify3D to send the data)
Build-Volume (X,Y,Z): 120,120,123
Nozzle Diameter: 0.3 <== Yes 0.3 works better !!!!
(You also can set 0.25 and smaller here and it still works, the slicer just reduces material and can print smaller perimeter than the nozzle size).
Filament diameter: 1.73 <== measured and works better for me
Number of extruders: 1
Heated bed: Yes
PROCESS SETTINGS:
Extruder:
Retract Distance 1.5mm
Extra Restart Distance: 0
Retract Vertical Lift: 0
Retract Speed: 50,0 mm/s
Coast at End: No
Wipe Nozzle: No
Layer:
Primary Layer Height: 0.1
Top Solid Layers: 4
Bottom Solid Layers: 3
Outline Shells: 2
First Layer Height: 100% <=== best results for the perf board
First Layer Width: 120% <== best results for the perf board
First Layer Speed: 60%
Additions:
Use Skirt/Brim: Yes (somehow a bug in Simplify3D will put the skirt much to fast, not respecting first layer speed reduction)
Skirt Layers: 1
Skirt Outlines: 2
Use Raft: Yes <=== best results for the perf board
Raft Layers: 2
Raft Offset: 3.0 mm
Separation Distance: 0.1 mm <=== best results for the perf board and removing raft
Raft Infill: 85 %
Disable raft base layers: No
Extruder 1 Temperature
Layer 1: 270
Layer 2: 260
Layer 3: 255
Heated Bed
Layer 1: 105
Cooling:
Adjust printing speed for layers below: 6.0 s
Allow speed reductions down to: 50%
Scripts:
Starting Script: <EMPTY> (transcoder inserts homing sequence automatically, no need to put anything here)
Ending Script:
M104 S0 ; turn off extruder
M140 S0 ; turn off bed
G28 ; home all axes (I inserted homing so the nozzle moves away from the part quickly when print finished)
Other:
Default Print Speed: 60.0 mm/s
X/Y Axis Movement Speed: 150mm/s
Z Axis Movement Speed: 50mm/s
Good luck,
Maik